abstract：:In primary prevention, traditional risk factors are a useful first step in determining who is at cardiovascular risk, however, it has been noted that a considerable number of those at risk cannot be identified on the basis of traditional risk factors alone. Among blood biomarkers, C-reactive protein (CRP), measured by...

journal_title：Herz

authors： Karakas M,Koenig W

更新日期：2009-12-01 00:00:00

abstract：:Therapy of sudden cardiac death is dominated by the implantable cardioverter defibrillator (ICD), which is highly efficient, but also has side effects. Therefore, the adequate selection of patients who could benefit from this therapy is crucial. For risk stratification, left ventricular ejection fraction is basically ...

journal_title：Herz

authors： Tönnis T,Kuck KH

更新日期：2009-11-01 00:00:00

abstract：:Interventional treatment of mitral insufficiency has recently become possible on a limited basis. The developed percutaneous procedures aim at minimizing the trauma in high-risk surgical candidates. Echocardiography has a major role in the preinterventional evaluation, during the interventional procedure, and in the p...

journal_title：Herz

authors： Hoffmann R,Altiok E

更新日期：2009-09-01 00:00:00

abstract：:Transcatheter aortic valve implantation (TAVI) using a balloon-expandable valve has been developed by the authors' group 7 years ago to offer a therapeutic solution to nonoperable or surgical high-risk patients with degenerative aortic stenosis. The technique and the devices used have rapidly evolved thereafter and TA...

journal_title：Herz

authors： Cribier A,Litzler PY,Eltchaninoff H,Godin M,Tron C,Bauer F,Bessou JP

更新日期：2009-08-01 00:00:00

abstract：:A 68-year-old woman was admitted to hospital because of chronic heart failure. The cause was a left-right shunt between the left sinus of Valsalva and the right atrium. The patient underwent surgery with shunt closure. Intraoperatively, the ramus circumflexus of the coronary artery was occluded. 2.5 years later the pa...

journal_title：Herz

authors： Felgendreher R,Cuneo A,Hochreuther S,Härtel D,Tebbe U

更新日期：2009-05-01 00:00:00

abstract：:The American Heart Association (AHA) radically changed the recommendations regarding endocarditis prophylaxis, if patients undergo dental work. For the vast majority of patients previously considered to be at significant risk for bacterial endocarditis (especially patients with degenerative and rheumatic heart disease...

journal_title：Herz

authors： Horstkotte D,Piper C

更新日期：2009-02-01 00:00:00

abstract：:Interventional catheterization for congenital heart disease has rapidly developed over the last 2 decades. The role of interventions has evolved from replacing surgery altogether in some cases to complementing surgery in others. The most commonly used approaches to common cardiac lesions such as persistent arterial du...

journal_title：Herz

authors： Krasemann T

更新日期：2008-12-01 00:00:00

abstract：:The discovery of an intracardial mass in patients presents a serious diagnostic dilemma. The differential diagnosis of this condition may seem abundant, but myxomas and intracardial thrombosis are the most frequent diagnoses. A connection between pregnancy and the presence of thrombosis has been documented frequently....

journal_title：Herz

authors： Velicki L,Milosavljević A,Majin M,Vujin B,Kovacević P

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:: Drug-eluting stents (DES) have been shown to reduce the risk of in-stent stenosis, one of the major problems of percutaneous coronary intervention (PCI) with implantation of baremetal stents. DES are approved in Germany since 2002. The following study is based on data of the ALKK PCI registry a...

journal_title：Herz

authors： Klein B,Zahn R,Heer T,Hochadel M,Tebbe U,Darius H,Kerber S,Schumacher B,Grube E,Hauptmann KE,Glunz HG,Senges J,Zeymer U

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Cardiac involvement may precede the onset of muscular manifestations in Becker muscular dystrophy (BMD), but Wolff-Parkinson-White (WPW) syndrome has not been reported as initial cardiac manifestation of BMD. CASE STUDY:In a 43-year-old, HIV-negative male, WPW syndrome was diagnosed at age 26 years upon a r...

journal_title：Herz

authors： Finsterer J,Stöllberger C,Quasthoff S

更新日期：2008-06-01 00:00:00

abstract：:This review summarizes some information on the management of diabetic patients at risk for or with already established coronary artery disease. Improved knowledge among diabetologists regarding treatment and prevention of cardiovascular complications and among cardiologists regarding diabetology is a prerequisite for ...

journal_title：Herz

authors： Anselmino M,Gohlke H,Mellbin L,Rydén L

更新日期：2008-04-01 00:00:00

abstract：:Myocardial infarction (MI) as an acute and life-threatening complication of coronary heart disease is one of the most frequent causes of death in Germany. Therefore, diagnosis, risk stratification and treatment of acute MI are of great clinical relevance. Specific recommendations concerning diagnosis of acute MI can b...

journal_title：Herz

authors： Weber M,Hamm C

更新日期：2008-03-01 00:00:00

abstract：:Management of acute ST elevation myocardial infarction (STEMI) demands rapid and complete reperfusion of the infarct-related artery (IRA). With postinfarction prognosis depending on time delay from onset of symptoms to complete reperfusion (TIMI 3 flow) of the IRA, primary percutaneous coronary intervention (PPCI) per...

journal_title：Herz

authors： Schneider H,Ince H,Rehders T,Körber T,Weber F,Kische S,Chatterjee T,Nienaber CA,Drip&Ship-Netzwerk (District of Rostock Infarct Project & Shipping Patients).

更新日期：2007-12-01 00:00:00

abstract：:The endothelium, the monolayer covering the inner surface of blood vessels, plays a pivotal role in the regulation of vascular tone and structure, as well as vascular inflammation and thrombosis, i.e., of key events of the atherosclerotic disease process and its clinical complications, such as myocardial infarction an...

journal_title：Herz

authors： Giannotti G,Landmesser U

更新日期：2007-10-01 00:00:00

abstract：:Although viral myocarditis has been mostly attributed to enterovirus and adenovirus infection until recently, the association with parvovirus B19 in Europe and hepatitis C virus in Asia has lately been noted. Clinical trials of antiviral agents, such as interferons, are in progress. Whereas immunosuppression with cort...

journal_title：Herz

authors： Matsumori A

更新日期：2007-09-01 00:00:00

abstract：:Leg artery stenoses often indicate generalized atherosclerosis of the arterial circulation. They can easily and reliably be diagnosed by the family physician or the nurse with Doppler ultrasound measurements and the calculation of the ankle-brachial index (ABI). A decreased value (< 0.9) is not only a sign of peripher...

journal_title：Herz

authors： Diehm C,Allenberg JR,Pittrow D,Darius H

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Serum cholesterol is positively associated with the risk of developing coronary heart disease. The aim of this study was to determine the relation between response of coronary arteries to ergonovine provocation and lipid profile in patients with nonsignificant coronary artery disease. PATIENTS A...

journal_title：Herz

authors： Nedeljkovic MA,Ostojic MC,Beleslin BD,Nedeljkovic I,Milic N,Vukcevic V,Stojkovic S,Saponjski J,Orlic D,Djordjevic-Dikic A,Stepanovic J,Giga V,Petrasinovic Z,Arandjelovic A,Beleslin B,Kanjuh V

更新日期：2007-06-01 00:00:00

abstract：:Identification of familial forms of different diseases has provided a unique opportunity to study how changes in the structure of a gene create a dysfunction in the physiology of the resulting protein. Changes in the genes encoding for ion channels produce modifications in the function of the channel. Changes in the s...

journal_title：Herz

authors： Brugada J,Brugada R,Brugada P

更新日期：2007-05-01 00:00:00

abstract：:Venous disease of the lower extremities comprises several common conditions such as varicose veins, superficial thrombophlebitis, deep venous thrombosis and chronic venous insufficiency. The high prevalence and increasing incidence with age of these disorders impose relevant diagnostic and therapeutic concerns. Varico...

journal_title：Herz

authors： Do DD,Husmann M

更新日期：2007-02-01 00:00:00

abstract：:Highly purified omega-3 polyunsaturated fatty acids (PUFAs) (Omacor) is the focus of an extensive and ambitious clinical development program that seeks to build on the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione study. Studies currently in progress inclu...

journal_title：Herz

authors： Vik H

更新日期：2006-12-01 00:00:00

abstract：:The presence of intraventricular obstruction is a powerful predictor of outcome in patients with hypertrophic cardiomyopathy (HCM) and, when associated with severe, drug-refractory symptoms, should be managed aggressively. Resting left ventricular outflow obstruction is found in approximately 20% of the patients, clas...

journal_title：Herz

authors： Cecchi F,Olivotto I,Nistri S,Antoniucci D,Yacoub MH

更新日期：2006-12-01 00:00:00

abstract：:Acute heart failure and especially its most severe form, cardiogenic shock, remain the final common pathway to death in a substantial number of patients with acute myocardial infarction (MI). Several studies demonstrated that mechanical reperfusion of occluded coronary arteries by percutaneous coronary intervention (P...

journal_title：Herz

authors： Poerner TC,Ferrari M,Brehm BR,Figulla HR

更新日期：2006-11-01 00:00:00

abstract：:While there is generell agreement that patients with aortic stenosis (AS) who have already developed symptoms, such as exertional dyspnea, angina or dizziness and syncope, require urgent surgery because of their otherwise very poor outcome, the management of asymptomatic severe AS remains controversial. Although preve...

journal_title：Herz

authors： Baumgartner H

更新日期：2006-10-01 00:00:00

abstract：:The prevalence of overweight and obesity in children and adolescents is increasing. In Germany, 10-20% of children and youth are overweight and obese. Childhood obesity is associated with cardiovascular and other comorbidities. 25% suffer from arterial hypertension and/or hypercholesterolemia, 1% from diabetes mellitu...

journal_title：Herz

authors： Graf C,Dordel S,Tokarski W,Predel HG

更新日期：2006-09-01 00:00:00

abstract：:The case of a 45-year-old man is reported who was an active competitive sportsman up to his 38th year. In fall of 1998, exercise limitation was noted. The cardiologic work-up revealed dilated cardiomyopathy. In spite of intensive medical therapy clinical course deteriorated within the next 3 years, cardiologic finding...

journal_title：Herz

authors： Brune S,Kroidl RF

更新日期：2006-09-01 00:00:00

abstract：:The aortic valve consists of three cusps attached to the wall of the aortic root. During the cardiac cycle, the aortic root undergoes complex movements that precede and aid opening and closing of the aortic valve. The aortic valve cusps themselves form thin-walled pocket-like structures, made from specialized tissue w...

journal_title：Herz

authors： Bechtel JF,Erasmi AW,Misfeld M,Sievers HH

更新日期：2006-08-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) is a strong, independent predictor of cardiovascular events and all-cause mortality. Patients with LVH are at increased risk for stroke, coronary heart disease, congestive heart failure, and sudden cardiac death. Hypertension is a major influence on the development of LVH. The progno...

journal_title：Herz

authors： Krauser DG,Devereux RB

更新日期：2006-06-01 00:00:00

abstract：:The rapid increase of morbid obesity has become an important task in the Western world in recent years. Since conservative treatments have failed to prove sufficient efficacy, surgery has turned out to be the most powerful option in treating morbid obesity. In this paper, the different surgical techniques with their a...

journal_title：Herz

authors： Wildi S,Müller MK,Clavien PA,Weber M

更新日期：2006-05-01 00:00:00

abstract：:Access to the intrinsic cardiac autonomic nervous system can now be achieved via percutaneous catheter stimulation techniques. Thereby, cardiac functions like atrioventricular nodal conduction, sinus cycle length and ventricular inotropy can be dynamically regulated. The present article provides examples of this new t...

journal_title：Herz

authors： Schauerte P,Schimpf T,Mischke K,Zarse M,Schmid M,Plisiene J,Maurath P,Kelm M,Pauza DH

更新日期：2006-04-01 00:00:00

abstract：:Besides diagnosis of the mechanism of mitral regurgitation accurate evaluation of the severity is of critical importance for the assessment of prognosis and planning of therapy. Current recommendations are differentiating two levels of evaluation of severity, (1) a rapid, basic evaluation, and (2) an extended, quantit...

journal_title：Herz

authors： Buck T,Plicht B,Erbel R

更新日期：2006-02-01 00:00:00

abstract：:Appraisal of the risk to which outpatients with chest pain are exposed is an important clinical problem that frequently occurs. The need to decide in day-to-day practice between a conservative or invasive approach in patients with chest pain is often difficult and the decision has grave implications. Stress echocardio...

journal_title：Herz

authors： Leischik R,Erbel R

更新日期：2005-12-01 00:00:00

abstract：:Implantable defibrillators (ICDs) have to be replaced after 4-6 years due to battery depletion. Therefore, 195-267 ICDs may be necessary for 100 ICD patients, if device longevity is 6 and 4 years, respectively. In Germany, 35% of all ICDs were replacements in 2003. The percentage of replacements will probably increase...

journal_title：Herz

authors： Bänsch D,Kuck KH

更新日期：2005-11-01 00:00:00

abstract：:New therapeutic options such as the highly active antiretroviral therapy (HAART) have significantly improved morbidity and mortality of HIV-infected patients. Consequently, age-related diseases become more manifest. In addition, HIV infection itself causes certain cardiovascular morbidity. Therefore, treatment of card...

journal_title：Herz

authors： Egger S,Drewe J

更新日期：2005-09-01 00:00:00

abstract：:Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a primary myocardial disorder that is characterized by localized or diffuse atrophy of predominantly right ventricular myocardium with subsequent replacement by fatty and fibrous tissue. Arrhythmias of right ventricular origin are the main clinical manifestatio...

journal_title：Herz

authors： Haverkamp W,Rolf S,Osterziel KJ,Dietz R,Peters S

更新日期：2005-09-01 00:00:00

abstract：:I. The actual data base on the decision-making process of indication for revascularization reveals that angiographic severity of coronary artery disease (CAD) is the primary determinant of referral to coronary interventional procedures. Several recent studies demonstrated that after an acute myocardial infarction, wom...

journal_title：Herz

authors： Tillmanns H,Waas W,Voss R,Grempels E,Hölschermann H,Haberbosch W,Waldecker B

更新日期：2005-08-01 00:00:00

abstract：:During the last decade, we have witnessed substantial improvements in the therapeutic options for pulmonary arterial hypertension (PAH), including true innovations targeting some of the mechanisms involved in the pathogenesis of this devastating disease. Intravenous epoprostenol was the first drug to improve symptoms ...

journal_title：Herz

authors： Hoeper MM

更新日期：2005-06-01 00:00:00

abstract：:Direct inhibition of thrombin is a promising new strategy for the treatment of cardiovascular disease and thrombosis. Three intravenous (lepirudin, bivalirudin and argatroban) and one oral direct thrombin inhibitor (ximelagatran) are currently available and approved for some clinical indications in the treatment of ca...

journal_title：Herz

authors： Ahrens I,Bode C

更新日期：2005-05-01 00:00:00

abstract：:An electrophysiological study (EPS) and a programmed ventricular stimulation (PVS) are strongly recommended and clearly indicated before the implantation of a cardioverter defibrillator (ICD), if patients present with a cardiac arrest and no structural heart disease or a hypertrophic cardiomyopathy. In these patients ...

journal_title：Herz

authors： Bänsch D,Antz M

更新日期：2005-03-01 00:00:00

abstract：:The term "chest pain with normal coronary arteries" encompasses a large number of different cardiac pathophysiological abnormalities, including impairment of coronary flow reserve, endothelial dysfunction, and early atherosclerosis that, in most cases, cannot be readily differentiated one from the other. To study earl...

journal_title：Herz

authors： Bugiardini R

更新日期：2005-02-01 00:00:00

abstract：:It is now generally recognized that atherosclerosis is a chronic inflammatory disease, characterized by overrecruitment of leukocytes (monocytes and T-cells) to the site of inflammation. Vascular injury in response to cardiovascular risk factors promotes endothelial dysfunction, resulting in enhanced adhesion molecule...

journal_title：Herz

authors： Steffens S,Mach F

更新日期：2004-12-01 00:00:00